Hyponatremia May Reflect Severe Inflammation in Children with Kawasaki Disease.
10.3339/chikd.2015.19.2.159
- Author:
I Re LEE
1
;
Se Jin PARK
;
Ji Young OH
;
Gwang Cheon JANG
;
Uria KIM
;
Jae Il SHIN
;
Kee Hyuck KIM
Author Information
1. Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea. shinji@yuhs.ac
- Publication Type:Original Article
- Keywords:
Kawasaki disease;
hyponatremia;
inflammation;
cardiovascular abnormalities
- MeSH:
Bilirubin;
Blood Sedimentation;
Cardiovascular Abnormalities;
Child*;
Coronary Vessels;
Humans;
Hyponatremia*;
Inflammation*;
Leukocytes;
Logistic Models;
Mucocutaneous Lymph Node Syndrome*;
Neutrophils;
Retrospective Studies;
Risk Factors;
Sodium
- From:Childhood Kidney Diseases
2015;19(2):159-166
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The aim of the present study was to investigate the risk factors for the development of coronary artery lesions (CALs) and to determine whether hyponatremia is associated with CALs in children with Kawasaki disease (KD). METHODS: We retrospectively analyzed the data of 105 children with KD who were admitted to Ilsan Hospital between January 2000 and July 2011. RESULTS: Erythrocyte sedimentation rate (P = 0.013), total bilirubin levels (P = 0.017) were higher and serum sodium levels (P = 0.027) were lower in KD children with CALs than those without. White blood cell (WBC) counts (P = 0.006), neutrophil counts (P = 0.003) were higher and albumin levels (P = 0.009) were lower in KD children with hyponatremia than those without. On multiple logistic regression analysis, hyponatremia (P = 0.024) and intravenous immunoglobulin??resistance (P = 0.024) were independent risk factors for CALs in KD. Furthermore, serum sodium levels were correlated negatively with WBC counts (P = 0.004), neutrophil counts (P < 0.001), total bilirubin levels (P = 0.005) and positively with albumin levels (P = 0.009). CONCLUSION: Our study indicates that hyponatremia may reflect severe inflammation in children with KD.
