Effect of Herceptin combined with Taxol on patients with Her-2/neu overexpressing metastatic breast cancer.
- Author:
Rong-cheng LUO
1
;
Ai-min LI
;
Jun-yi ZHANG
;
Wang-jun LIAO
;
Chen-yang JI
;
Jing-xia MIAO
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Antibodies, Monoclonal; administration & dosage; adverse effects; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; therapeutic use; Breast Neoplasms; chemistry; drug therapy; Female; Humans; Middle Aged; Paclitaxel; administration & dosage; adverse effects; Receptor, ErbB-2; analysis; Trastuzumab
- From: Chinese Journal of Oncology 2004;26(1):52-54
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the efficacy and toxicity of recombinant humanized anti-Her-2/neu antibody (Herceptin) and Taxol for patients with Her-2/neu overexpressing metastatic breast cancer.
METHODSSixty patients with Her-2/neu overexpressing metastatic breast cancer were investigated. Of the 60 cases, 22 were treated with Herceptin and Taxol and 38 with Taxol and doxorubicin.
RESULTSThe total response rate (RR) of Herceptin and Taxol was 68.2%, and that of Taxol and doxorubicin was 44.7%. The RR of patients with Her-2/neu(+++) was 75%, while that of patients with Her-2/neu(++) was 50%. The major adverse effects were gastro-intestinal tract reactions, myopathy, bone marrow suppression and alopecia.
CONCLUSIONThe treatment with Herceptin and Taxol is effective and safe for patients with Her-2/neu overexpressing metastatic breast cancer. The therapeutic effect is related to the degree of Her-2/neu overexpression.
