Treatment of recurrent malignant brain gliomas by surgical excision combined with biodegradable polymers of interstitial chemotherapy.
- Author:
Song-tao QI
1
;
Bing-hui QIU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Brain Neoplasms; mortality; therapy; Combined Modality Therapy; Etoposide; administration & dosage; adverse effects; Female; Glioma; mortality; therapy; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; therapy; Polymers; administration & dosage
- From: Chinese Journal of Oncology 2004;26(1):58-61
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effectiveness of treatment of recurrent malignant brain gliomas by surgical excision combined with biodegradable polymers of interstitial chemotherapy.
METHODSIn 30 patients with recurrent malignant brain gliomas, the tumor was surgically removed and Vp-16 biodegradable polymers were implanted during operation in the tumor bed at a dose of 100 - 150 mg. The patients were followed up for 3 - 24 months, and the results were compared with 46 cases with the recurrent malignant brain gliomas who received operation only.
RESULTSAt 3, 6, 12, 24 months after treatment, the recurrent rate was 16.7%, 30%, 50% and 83.3%, respectively; the mortality rate was 6.67%, 20%, 40% and 70%, respectively. All the patients had no apparent side-effects of chemotherapy.
CONCLUSIONSurgical treatment combined with interstitial chemotherapy with biodegradable Vp-16 polymers improves the treatment result of recurrent malignant brain gliomas compared to surgery alone.
