A Case of Hypereosinophilic Syndrome with Bladder Involvement in a 7-Year-Old Boy.
10.3339/chikd.2015.19.2.167
- Author:
Yoon Kyoung PARK
1
;
Hyung Eun YIM
;
Kee Hwan YOO
Author Information
1. Department of Pediatrics, College of Medicine, Korea University, Seoul, 152- 703, South Korea. he-yim@hanmail.net
- Publication Type:Case Report
- Keywords:
Hypereosinophilic syndrome;
Eosinophilic cystitis;
Hypereosinophilia
- MeSH:
Anti-Bacterial Agents;
Biopsy;
Child*;
Cystitis;
Dyspnea;
Dysuria;
Electrocardiography;
Eosinophils;
Hematuria;
Humans;
Hypereosinophilic Syndrome*;
Inflammation;
Male*;
Proteinuria;
Respiratory Function Tests;
Steroids;
Thorax;
Urinary Bladder*;
Vomiting
- From:Childhood Kidney Diseases
2015;19(2):167-170
- CountryRepublic of Korea
- Language:English
-
Abstract:
Hypereosinophilic syndrome (HES) is characterized by the presense of hypereosinophilia with evidence of target organ damage. We report a patient diagnosed with eosinophilic cystitis and HES. A 7 year old boy had hematuria, dysuria, and increased urinary frequency for 1 day. Laboratory examinations revealed hypereosinophilia (eosinophils, 2,058/microL), hematuria, and proteinuria. Abdominal sonography revealed diffuse and severe wall thickening of the bladder. The patient was treated initially with antibiotics. However, his symptoms did not improve after 7 days. A computed tomography scan demonstrated severe wall thickening of the bladder and the hypereosinophilia persisted (eosinophils, 2,985/microL). The patient complained of chest discomfort, dyspnea, epigastric pain, and vomiting on hospital day 10. Parasitic, allergic, malignancy, rheumatologic, and immune workups revealed no abnormal findings. Chest X-rays, electrocardiography, and a pulmonary function test were normal; however, the hypereosinophilia was aggravated (eosinophils, 3,934/microL). Oral deflazacort was administered. A cystoscopic biopsy showed chronic inflammation with eosinophilic infiltration. The patient's respiratory, gastrointestinal, and urinary symptoms improved after 6 days of steroids, and he was discharged. The eosinophil count decreased dramatically (182/microL). The hypereosinophilia waxed and waned for 7 months, and the oral steroids were tapered and stopped. This case describes a patient diagnosed with eosinophilic cystitis and HES.
