Expression of HGF and its receptor c-Met in renal cell carcinoma.
- Author:
Bing-bing SHI
1
;
Xiang-hong ZHANG
;
Hui-jun WANG
;
Han-zhong LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Carcinoma, Renal Cell; metabolism; pathology; Female; Hepatocyte Growth Factor; biosynthesis; genetics; Humans; Kidney Neoplasms; metabolism; pathology; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Proto-Oncogene Proteins c-met; biosynthesis; genetics; RNA, Messenger; biosynthesis
- From: Chinese Journal of Oncology 2004;26(6):356-358
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the clinical significance of expression of hepatic growth factor (HGF) and its receptor c-Met in renal cell cancer (RCC).
METHODSTwenty-six patients with RCC and 10 benign renal tumor patients were examined. The expression of HGF and c-Met mRNA was detected using Northern blot. GAPDH was used as the internal control.
RESULTSTwenty-one out of 26 patients with RCC had positive gene expression of HGF and c-Met with the positive rate of 80.8%. According to the tumor TNM staging, the more advanced the cancer had a stronger expression of HGF and c-Met, the expression of c-Met was higher than that of HGF in the RCC. Whereas in the control group with benign tumor, the expression of c-Met was rather mild.
CONCLUSIONThe result suggests that HGF and its receptor c-Met may play an important role in the development and progression of renal cancer, which may also imply a potential clinical significance in diagnosing and assessing prognosis of RCC.
