Study of prognostic factors in patients with stage I non-small cell lung cancer.
- Author:
Zhi-qin JIANG
1
;
Guo-liang JIANG
;
Da-ren SHI
;
Rong-xuan ZHANG
;
Xiao-long FU
;
Hao QIAN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; mortality; pathology; surgery; Cell Differentiation; Chemotherapy, Adjuvant; Female; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Lung Neoplasms; mortality; pathology; surgery; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasm Staging; Oncogenes; Prognosis; Retrospective Studies; Survival Rate
- From: Chinese Journal of Oncology 2004;26(6):364-368
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze the prognostic factors in patients with stage I non-small cell lung cancer (NSCLC).
METHODSFifty-eight patients with stage I NSCLC treated from 1991 to 1995 were retrospectively reviewed. The clinical features, histopathology and prognostic factors were analyzed by SPSS10.0 statistic software. The expression of c-myc, MDM2, c-erbB-2, EGFR, p53, p14(ARF), p16(INK4), p21(WAF1) and nm23 was detected by immunohistochemical assay. The overall survival rate, local-regional control rate and distant metastasis rate were observed.
RESULTSThe overall survival rate, local-regional recurrent rate and distant metastasis rate were 71.1%, 11.1% and 33.5%, respectively. In univariate analysis, tumor cell differentiation was an independent prognostic factor (P = 0.028); overexpression of c-myc or c-erbB-2 had significantly poor overall survival and high distant metastasis rate (P < 0.05). The total oncogene immunoreactive score (IRS) and comprehensive IRS were associated with poor overall survival. In multivariate analysis, tumor cell differentiation and comprehensive IRS were independent prognostic factors for overall survival. Among the high-risk group of patients, those who had received chemotherapy seemed to have a higher overall survival rate and a lower distant metastasis rate in this study, but the difference was not statistically significant.
CONCLUSIONFor stage I NSCLC patients, tumor cell differentiation and comprehensive IRS are independent prognostic factors for overall survival. Adjuvant chemotherapy might somehow improve the survival for the patients with high-risk factors.
