Cytokine responses after lobectomy for early non-small cell lung cancer: a prospective randomized comparison of video-assisted thoracic surgery and open thoracotomy.
- Author:
Yi ZHANG
1
;
Ge-ning JIANG
;
Qun WANG
;
Yu-ming ZHU
;
Jia-an DING
;
Chang CHEN
;
Xiao-feng CHEN
;
Hao WANG
;
Bo-xiong XIE
;
Wen-tao LI
;
Wen-pu TONG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Carcinoma, Non-Small-Cell Lung; blood; surgery; Female; Follow-Up Studies; Humans; Interleukin-10; blood; Interleukin-6; blood; Interleukin-8; blood; Interleukins; blood; Lung Neoplasms; blood; surgery; Male; Middle Aged; Pneumonectomy; methods; Prospective Studies; Thoracic Surgery, Video-Assisted; Thoracotomy; Treatment Outcome; Young Adult
- From: Chinese Journal of Surgery 2010;48(17):1285-1288
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo compare video-assisted thoracic surgery (VATS) and open thoracotomy (OT) on acute inflammatory responses and immunosuppression after lobectomy for early non-small cell lung cancer (NSCLC).
METHODSPresent prospective randomized study. OT or VATS lobectomy was performed in patients who met enter criteria and clinical data was collected. Plasma concentration of IL-6, IL-8 and IL-10 were measured before surgery and at postoperative day (POD) 1 and POD 3. There were 271 patients underwent lobectomy for early NSCLC, including of 133 patients in group VATS and 138 patients in group OT from January 2007 to June 2008. There were 132 males and 139 females, aging from 19 ∼ 70 years with a mean of (56 ± 8) years.
RESULTSCompared with OT group, shorter postoperative hospital stay [(8.2 ± 2.5) d vs. (9.8 ± 6.2) d, P = 0.03], lower morbidity rate (11.3% vs. 21.7%, P = 0.02) and lower increase of plasma concentration of IL-6 at POD 1 [(35 ± 25)% vs. (65 ± 43)%, P = 0.00], IL-6 at POD 3 [(14 ± 22)% vs. (55 ± 44)%, P = 0.00] and IL-10 at POD 1 [(25 ± 20)% vs. (43 ± 35)%, P = 0.00] were observed in patients of VATS group.
CONCLUSIONVATS lobectomy for early NSCLC is associated with less acute inflammatory responses and less immunosuppression when compared with OT.