Characteristics of combining loss of heterozygosity of 1p/19q in glioma.
- Author:
Xiang-li CUI
1
;
Zhi-gang ZHAO
;
Xiao-hui REN
;
Da-li SUI
;
Jun-sheng CHU
;
Kai TANG
;
Chun ZENG
;
Song LIN
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Brain Neoplasms; genetics; Chromosomes, Human, Pair 1; genetics; Chromosomes, Human, Pair 19; genetics; Female; Glioma; genetics; Humans; Loss of Heterozygosity; Male; Middle Aged; Young Adult
- From: Chinese Journal of Surgery 2010;48(11):852-855
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVESTo find possible factors correlated with combined loss of heterozygosity (LOH) of 1p and 19q.
METHODSThe status of 1p and 19q of 138 glioma specimen from January 2009 to December 2009 was evaluated by Fluorescence in situ hybridization (FISH) method, and the frequencies of combining LOH of 1p/19q were compared between different pathologies, brain sub-regions, genders and ages.
RESULTSThe frequencies of combined LOH of 1p and 19q of oligodendroglial (81.3%) and oligo astrocytic tumors (55.8%) were significantly higher than that of astrocytic tumor (22.2%) (P < 0.01), and the frequency of oligodendroglial tumor was significantly higher than that of oligo astrocytic tumor (P < 0.05). The frequency of combining LOH of 1p and 19q in frontal lobe (61.8%) was higher than that in temporal (31.8%) and insular lobes (34.6%) (P < 0.05).
CONCLUSIONCombining LOH of 1p and 19q has significant correlation with the pathologies and brain sub-regions.
