Clinical and pathological correlation of the microdeletion of Y chromosome for the 30 patients with azoospermia and severe oligoasthenospermia.
- Author:
Han-Sun CHIANG
1
;
Shauh-Der YEH
;
Chien-Chih WU
;
Boo-Chung HUANG
;
Hui-Ju TSAI
;
Chia-Lang FANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Chromosome Deletion; Chromosomes; Chromosomes, Human, Y; Counseling; Gene Deletion; Humans; Male; Middle Aged; Oligospermia; pathology; Sperm Injections, Intracytoplasmic; Testis; pathology; Tissue Embedding
- From: Asian Journal of Andrology 2004;6(4):369-375
- CountryChina
- Language:English
-
Abstract:
AIMTo review the accumulated 30 patients with different area of Y chromosome microdeletions, focusing on their correlation with the clinical and pathological findings.
METHODSA total of 334 consecutive infertile men with azoospermia (218 patients) and severe oligoasthenospermia (116 patients) were screened. Complete physical and endocrinological examinations, general chromosome study and multiplex polymerase chain reaction assay to evaluate the Y chromosome microdeletion were performed. Ten patients received testicular biopsy. Then the clinical and pathological findings were analyzed with reference to the areas of Y chromosome microdeletion.
RESULTSThere is a decline of the percentage of sperm appearing in semen in the group that the gene deletion region from AZFc to AZFb. The clinical evidence of the impairment (decreased testicular size and elevated serum FSH) is also relevantly aggravated in this group. However, the pathology of testicular biopsy specimen was poorly correlated with the different deletion areas of the Y chromosome, which may be due to the limited number of specimens.
CONCLUSIONThe clinical correlation of spermatogenic impairment to the different AZF deletion regions may provide the information for the infertile couples in pre-treatment counseling.
