Effect of beta radiation on TGF-beta1 and bFGF expression in hyperplastic prostatic tissues.
- Author:
Qing-Jie MA
1
;
Xin-Quan GU
;
Xia CAO
;
Jie ZHAO
;
Xiang-Bo KONG
;
Yu-Xin LI
;
Shan-Yu CAI
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Aged, 80 and over; Beta Particles; Case-Control Studies; Fibroblast Growth Factor 2; metabolism; radiation effects; Gene Expression; Humans; Immunohistochemistry; Male; Middle Aged; Prostate; metabolism; radiation effects; Prostatic Hyperplasia; metabolism; radiotherapy; Strontium Radioisotopes; therapeutic use; Transforming Growth Factor beta; metabolism; radiation effects; Transforming Growth Factor beta1; Yttrium Radioisotopes; therapeutic use
- From: Asian Journal of Andrology 2005;7(1):49-54
- CountryChina
- Language:English
-
Abstract:
AIMTo investigate the transforming growth factor beta1 (TGF-beta1) and basic fibroblast growth factor (bFGF) expressions in benign prostatic hyperplasia (BPH) and the effect of beta-radiation.
METHODSTGF-beta1 and bFGF expression was studied by means of an immunohistochemical method in nine normal prostatic (NP) tissues, 15 hyperplastic prostatic tissues and 35 hyperplastic prostatic tissues treated with 90Sr/90Y.
RESULTSThe TGF-beta1 expression in the epithelium and stroma of normal prostatic tissues was 68.2 % +/- 10.5 % and 29.7 % +/- 4.6 %, respectively, while it was 64.8 % +/- 9.3 % and 28.6 % +/- 4.1 %, respectively, in hyperplastic prostatic tissues. Compared with the controls, TGF-beta1 expression in the epithelia and stroma of BPH treated with 90Sr/90Y increased significantly (P <0.01). The bFGF expression in epithelia and stroma of normal prostatic tissues was 17.4 % +/- 3.7 % and 42.5 % +/- 6.8 %, respectively, and was 46.3 % +/- 8.2 % and 73.2 % +/- 12.1 %, respectively, in hyperplastic prostatic tissues. Compared with the controls, expressions of bFGF in the epithelia and stroma of BPH treated with a 90Sr/90Y prostatic hyperplasia applicator decreased significantly (P <0.01).
CONCLUSIONExposure of beta-rays had noticeable effects on BPH tissues, enhancing TGF-beta1 expression and inhibiting bFGF expression.
