Expression of monocyte chemotactic protein 1 and vascular endothelial growth factor in nasal polyps.

Author: Cui-ping SHE ¹ ; Gui-mei GUAN ; Dong-dong ZHU ; Zhen DONG
Author Information

1. Department of Otorhinolaryngology Head and Neck Surgery, China-Japan Union Hospital, Jilin University, Changchun 130033, China.
Publication Type:Journal Article
MeSH: Adult; Aged; Chemokine CCL2; metabolism; Female; Humans; Male; Middle Aged; Nasal Mucosa; metabolism; Nasal Polyps; metabolism; pathology; Vascular Endothelial Growth Factor A; metabolism
From: Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2007;42(7):508-510
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo evaluate the relationship between the expression of monocyte chemotactic protein 1 (MCP-1) and vascular endothelial growth factor (VEGF) in nasal polyp (NP) tissues and the role of MCP-1 in the formation of nasal polyps.
METHODSForty nasal polyp tissues obtained from NP patients were used to detect the expression of MCP-1 and VEGF at the levels of protein and mRNA by immunohistochemical and in situ hybridization assay. Twenty-five inferior turbinate (IT) samples obtained from chronic rhinitis patients were used as control.
RESULTSThe expression of MCP-1 and VEGF was higher in NP tissue than in IT at protein and mRNA levels (P <0.01). The expression of these two cytokines was positively correlated(r = 0.871, P <0.05).
CONCLUSIONSMCP-1 and VEGF were involved in the formation of nasal polyps.