Nasal and Exhaled Nitric Oxide in Allergic Rhinitis.
- Author:
Keon Jung LEE
1
;
Seok Hyun CHO
;
Seung Hwan LEE
;
Kyung TAE
;
Ho Joo YOON
;
Sang Heon KIM
;
Jin Hyeok JEONG
Author Information
- Publication Type:Original Article
- Keywords: Nitirc oxide; Nasal nitric oxide; Exhaled nitric oxide; Allergic rhinitis; Asthma
- MeSH: Asthma; Humans; Luminescence; Nitric Oxide; Rhinitis; Rhinitis, Allergic, Perennial
- From:Clinical and Experimental Otorhinolaryngology 2012;5(4):228-233
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVES: The primary aim of this study was to assess whether one can use levels of nasal nitric oxide (nNO) and exhaled nitric oxide (eNO) as a means of evaluation in allergic rhinitis. METHODS: We used a chemiluminescence analyzer to measure nNO and eNO in normal controls (n=34) and allergic rhinitis patients (n=35), and compared these measurements with various parameters of clinical symptoms and laboratory data. RESULTS: Mean nNO (389+/-119 ppb) in allergic rhinitis patients was significantly higher than normal controls (276+/-88 ppb). Without asthma, mean eNO (64.8+/-55.9 ppb) in allergic rhinitis patients was significantly higher than normal controls (33.0+/-24.0 ppb). In the persistent allergic rhinitis group, eNO concentration was significantly higher, while nNO concentration was significantly lower than the intermittent group. CONCLUSION: We can use nNO and eNO levels for evaluation of allergic rhinitis. However, we should consider the fact that nNO levels can be reduced, when symptoms are severe and long-lasting. Additionally, in allergic rhinitis, eNO can be elevated without asthma.
