Expression and clinical significance of Endostatin, vascular endothelial growth factor and fibroblast growth factor basic-2 in laryngeal carcinoma.
- Author:
Wei-wei LIU
1
;
Shu-jun ZHANG
;
Guang-huai HAN
;
Hui-jing SHI
;
Jun-ge WANG
;
Shu-ling DONG
;
Hong-xia LI
;
Guo-li LI
;
Qi-fen SUN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Carcinoma, Squamous Cell; metabolism; pathology; Endostatins; metabolism; Female; Fibroblast Growth Factor 2; metabolism; Gene Expression Regulation, Neoplastic; Humans; Laryngeal Neoplasms; metabolism; pathology; Male; Middle Aged; Neoplasm Staging; Prognosis; Vascular Endothelial Growth Factor A; metabolism
- From: Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2007;42(9):687-691
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the expression and clinical significance of Endostatin, vascular endothelial growth factor (VEGF) and fibroblast growth factor basic-2 (FGF-2) in the laryngeal squamous cell carcinoma (LSCC).
METHODSThe expression of Endostatin, VEGF and FGF-2 in 50 specimens of LSCC, 40 specimens of para-carcinoma and 10 specimens of normal laryngeal tissues were examined by Flow cytometry.
RESULTSCompared with para-carcinoma and normal laryngeal tissues, the expression level and positive rate of Endostatin, VEGF, FGF-2 in LSCC were different in statistics (P < 0.05); the expression level and positive rate of endostatin, VEGF, FGF-2 in LSCC are obviously higher than those in para-carcinoma and normal laryngeal tissues. The expression level and positive rate of Endostatin, VEGF, FGF-2 were no difference in statistics between para-carcinoma and normal laryngeal tissues (P > 0.05). The expression level and positive rate of Endostatin, VEGF, FGF-2 in LSCC were associated with lymphoid metastasis and clinical stage, not associated with age, sex and clinical group.
CONCLUSIONSEndostatin, VEGF and FGF-2 play important role in the incidence, development and prognosis of the LSCC.
