Effect of low-dose folate treatment on plasma homocystyeine and chemokine levels in patients with hyperhomocysteinemia.
- Author:
Chang-Lin LU
1
;
Guang WANG
;
Jing-Xuan GUO
Author Information
- Publication Type:Clinical Trial
- MeSH: Aged; Chemokines; blood; Female; Folic Acid; administration & dosage; therapeutic use; Homocysteine; blood; Humans; Hyperhomocysteinemia; blood; drug therapy; Male; Middle Aged; Treatment Outcome
- From: Acta Academiae Medicinae Sinicae 2008;30(3):342-343
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the effect of low-dose folate on plasma homocysteinemia (Hcy) and chemokine levels in patients with hyperhomocysteinemia (HHcy).
METHODSForty HHcy patients were treated with 0.8 mg/d folate for 6 months. Plasma levels of Hcy, monocyte chemoattractant protein-1 (MCP-1), interleukin-8 (IL-8), malondialdehyde (MDA), and superoxide dismutase (SOD) were measured before and after folate treatment.
RESULTSPlasma level of Hcy significantly decreased after folate treatment [(57.1 +/- 18.0) micromol/L vs (25.8 +/- 12.0) micromol/L, P <0.05]. However, the plasma levels of MCP-1, IL-8, SOD, and MDA were not changed after folate treatment.
CONCLUSIONFolate treatment can decrease the plasma Hcy level in HHcy patients; however, it has no obvious effects on the chemokine levels.
