Preoperative evaluation of liver function using 99mTc-diethyl iminodiacetic acid based on single photon emission computed tomography.
- Author:
Shun-da DU
1
;
Yi-lei MAO
;
Fang LI
;
Meng OUYANG
;
Jun-xiang TONG
;
Xin-ting SANG
;
Zhi-ying YANG
;
Xin LU
;
Tian-yi CHI
;
Hai-tao ZHAO
;
Yi-yao XU
;
Hai-feng XU
;
Shou-xian ZHONG
;
Jie-fu HUANG
Author Information
- Publication Type:Clinical Trial
- MeSH: Adult; Aged; Animals; Female; Humans; Liver Diseases; diagnosis; diagnostic imaging; physiopathology; Liver Function Tests; Male; Middle Aged; Postoperative Period; Preoperative Period; Radiopharmaceuticals; administration & dosage; Technetium Tc 99m Diethyl-iminodiacetic Acid; administration & dosage; Tomography, Emission-Computed, Single-Photon
- From: Acta Academiae Medicinae Sinicae 2008;30(4):409-414
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo establish a three-dimentional liver function evaluation system using 99mTc-diethyl iminodiacetic acid (99mTc-EHIDA) scintigraphy based on single photon emission computed tomography (SPECT).
METHODSTotally 16 patients with liver lesions were divided into cirrhosis group and non-cirrhosis group. SPECT was performed 2 days before operation and 5 days after operation. Serum liver functions were examined on the same day of scintigraphy. SPECT images of areas of interest of heart and liver were aquired. Time of the peak of EHIDA density in liver (Tpeak), five-minutes heart liver index (HLI5), blood clearance index (HH15), receptor index (LHL15), and the predictive values were calculated.
RESULTSTpeak was not significantly different between two groups, while HLI5, HH15, and LHL15 were significantly different (P = 0.033, P = 0.001, and P = 0.005). HLI, and LHL15 were significantly correlated with preoperative total protein and prealbumin levels (P = 0.003, P = 0.015, P = 0.022, P = 0.038) and post-operative prealbumin (P = 0.037, P = 0.042). The predictive values of HLI5 and LHL15 correlated well with postoperative HLI5 and LHL15 (r = 0.675, P = 0.016; r = 0.629, P = 0.028).
CONCLUSIONThe three-dimentional liver function evaluation system using 99mTc-EHIDA based on liver SPECT may facilitate the further studies of risks of liver surgery.
