AduoLa Fuzhenglin down-regulates microwave-induced expression of β1-adrenergic receptor and muscarinic type 2 acetylcholine receptor in myocardial cells of rats.
- Author:
Jing ZHANG
1
;
Rui Yun PENG
1
;
Ya Bing GAO
1
;
Shui Ming WANG
1
;
Lei Lei YANG
1
;
Li ZHAO
1
;
Ji DONG
1
;
Bin Wei YAO
1
;
Gong Min CHANG
1
;
Lu XIONG
1
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Down-Regulation; drug effects; Drugs, Chinese Herbal; pharmacology; Heart; drug effects; Male; Microwaves; adverse effects; Myocardium; cytology; metabolism; Protective Agents; pharmacology; Rats, Wistar; Receptor, Muscarinic M2; metabolism; Receptors, Adrenergic, beta-1; metabolism
- From: Biomedical and Environmental Sciences 2014;27(3):204-207
- CountryChina
- Language:English
- Abstract: This paper is aimed to study the effect of ADL on expression of β1-AR and M2-AchR in myocardial cells of rats exposed to microwave radiation. Immunohistochemistry, Western blot and image analysis were used to detect the expression of β1-AR and M2-AchR in myocardial cells at 7 and 14 d after microwave exposure. The results show that the expression level was higher in microwave exposure group and 0.75 g/(kg•d) ADL group than in sham operation group and significantly lower in 1.5 and 3.0 g/(kg•d) ADL groups than in microwave group. So we have a conclusion that the expression of β1-AR and M2-AchR is down-regulated in myocardial cells of rats exposed to microwave radiation. ADL can protect rats against microwave-induced heart tissue injury.
