A novel reassortant H2N3 influenza virus isolated from China.

Xiao Dan LI; Shu Mei Zou; Ye Zhang; Tian Bai; Rong Bao Gao; Xin Zhang; Jie WU; Yue Long Shu

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A novel reassortant H2N3 influenza virus isolated from China.

Author: Xiao Dan LI ¹ ; Shu Mei ZOU ¹ ; Ye ZHANG ¹ ; Tian BAI ¹ ; Rong Bao GAO ¹ ; Xin ZHANG ² ; Jie WU ² ; Yue Long SHU ¹
Author Information

1. Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory of Surveillance and Early warning on Infectious Disease, Key Laboratory for Medical Virology, National Health and family planning Commission, Beijing 102206, China.
2. Center for Disease Control and Prevention of Guangdong Province, Guangzhou 510300, Guangdong, China.
Publication Type:Journal Article
Keywords: Avian influenza; Gene analysis; H2N3
MeSH: Animals; China; Ducks; virology; Genome, Viral; Influenza A virus; genetics; isolation & purification; Influenza in Birds; virology; Phylogeny
From: Biomedical and Environmental Sciences 2014;27(4):240-249
CountryChina
Language:English
Abstract:
OBJECTIVETo analyze the genetic composition of a novel H2N3 virus isolate identified from a duck cage swab in a live poultry market (LPM) in 2009 in Guangdong province of China.
METHODSPCR-positive specimens were inoculated into embryonated chicken eggs and subtyped by conventional RT-PCR. All segments of the virus A/environment/Guangdong/2/2009 were sequenced, and phylogenetic trees were constructed and analyzed.
RESULTSThe genes of this virus belong to Eurasian-lineage avian viruses. The virus is a reassortant with the HA gene from an H2N2 virus and the NA gene from an H5N3 virus. The PB1, PB2, and NP genes were from an H4N6 virus, the PA was from an H3N8 virus, the M gene was from an H1N3 virus, and the NS gene was from an H10N6 virus.
CONCLUSIONA novel avian-origin reassortant H2N3 influenza virus was detected in a live poultry market. Its potential impacts and evolution should be closely monitored.