Anti-nociceptive effect in mice of thillai flavonoid rutin.

Gurudeeban Selvaraj; Satyavani Kaliamurthi; Ramanathan Thirungnasambandam; Lalitha Vivekanandan; Thangavel Balasubramanian

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Anti-nociceptive effect in mice of thillai flavonoid rutin.

Author: Gurudeeban SELVARAJ ¹ ; Satyavani KALIAMURTHI ¹ ; Ramanathan THIRUNGNASAMBANDAM ¹ ; Lalitha VIVEKANANDAN ² ; Thangavel BALASUBRAMANIAN ¹
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1. Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai 608502, Tamil Nadu, India.
2. Nandha College of Pharmacy and Research Institute, Erode, Tamil Nadu, India.
Publication Type:Letter
MeSH: Analgesics; isolation & purification; therapeutic use; Animals; Drug Evaluation, Preclinical; Euphorbiaceae; chemistry; Female; Male; Mice; Pain; drug therapy; Phytotherapy; Plant Extracts; chemistry; therapeutic use; Rutin; isolation & purification; therapeutic use
From: Biomedical and Environmental Sciences 2014;27(4):295-299
CountryChina
Language:English
Abstract: We investigated the anti-nociceptive effect of Excoecaria agallocha (E.agallocha) against chemically and thermally induced nociception, Albino mice received a dose of 10, 15, 20, or 25 mg/kg of alkaline chloroform fraction (Alk-CF) of E.agallocha by oral administration. Compared with controls, Alk-CF decreased the writhing numbers (P<0.01) in a dose dependent manner. Further we determined that, Alk-CF contained, a potent compared to control, also potent anti-nociceptive agent that acted via opioid receptors and using HPLC, identified this compound as Rutin. Docking simulation demonstrated that Rutin interacted strongly with cyclooxygenase, forming a number of specific hydrogen bonds. In conclusion we have identified peripheral and central anti-nociceptive activities of E.agallocha that involve opioid receptor, and in which the active compound is Rutin.