Application of gas chromatography-mass spectrometry in analyzing pharmacokinetics and distribution of deltamethrin in miniature pig tissues.

Pan Zhu; Sai Fan; Jian Hong Zou; Hong Miao; Jing Guang LI; Guo Wen Zhang; Yong Ning WU

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Application of gas chromatography-mass spectrometry in analyzing pharmacokinetics and distribution of deltamethrin in miniature pig tissues.

Author: Pan ZHU ^{1
,

2} ; Sai FAN ³ ; Jian Hong ZOU ⁴ ; Hong MIAO ⁵ ; Jing Guang LI ¹ ; Guo Wen ZHANG ⁶ ; Yong Ning WU ¹ ;
Author Information

1. State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi, China
2. Key Laboratory of Food Safety Risk Assessment of Ministry of Health, China National Center for Food Safety Risk Assessment, Beijing 100021, China.
3. Institute of Nutrition and Food Safety, Beijing Centre of Disease Control and Prevention, Beijing 100013, China.
4. The Second Artillery General Hospital, Beijing 100088, China.
5. Key Laboratory of Food Safety Risk Assessment of Ministry of Health, China National Center for Food Safety Risk Assessment, Beijing 100021, China.
6. State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi, China.
Publication Type:Journal Article
Keywords: Deltamethrin; GC-MS; Miniature pig; Pharmacokinetics; Tissue distribution
MeSH: Absorption; Animals; Gas Chromatography-Mass Spectrometry; Models, Animal; Nitriles; pharmacokinetics; Pyrethrins; pharmacokinetics; Swine; Swine, Miniature; Tissue Distribution
From: Biomedical and Environmental Sciences 2014;27(6):426-435
CountryChina
Language:English
Abstract:
OBJECTIVETo characterize the pharmacokinetics and distribution profiles of deltamethrin in miniature pig tissues by gas chromatography-mass spectrometry (GC-MS).
METHODSPharmacokinetics and distribution of deltamethrin in blood and tissues of 30 miniature pigs were studied by GC-MS after oral administration of deltamethrin (5 mg/kg bw). Data were processed by 3P97 software.
RESULTSThe serum deltamethrin level was significantly lower in tissues than in blood of miniature pigs. The AUC0-72 h, Cmax, of deltamethrin were 555.330 ± 316.987 ng h/mL and 17.861 ± 11.129 ng/mL, respectively. The Tmax, of deltamethrin was 6.004 ± 3.131 h.
CONCLUSIONThe metabolism of deltamethrin in miniature pigs is fit for a one-compartment model with a weighting function of 1/C2. Deltamethrin is rapidly hydrolyzed and accumulated in miniature pig tissues.