Allergy-related evidences in relation to serum IgE: data from the China state key laboratory of respiratory disease, 2008-2013.

Bao Qing Sun; De Hui Chen; Pei Yan Zheng; Hui Min Huang; Wen Ting Luo; Guang Qiao Zeng; Xiao Wen Zhang

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Allergy-related evidences in relation to serum IgE: data from the China state key laboratory of respiratory disease, 2008-2013.

Author: Bao Qing SUN ¹ ; De Hui CHEN ² ; Pei Yan ZHENG ¹ ; Hui Min HUANG ¹ ; Wen Ting LUO ¹ ; Guang Qiao ZENG ¹ ; Xiao Wen ZHANG ³
Author Information

1. State Key Laboratory of Respiratory Disease, National Clinical Center for Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, Guangdong, China.
2. Department of Pediatrics, First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, Guangdong, China.
3. Department of Otorhinolaryngology-Head & Neck Surgery, First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, Guangdong, China.
Publication Type:Journal Article
Keywords: Allergen; Allergy; Serum IgE; Symptoms
MeSH: Adolescent; Adult; Aged; Aged, 80 and over; Allergens; immunology; Child; Child, Preschool; China; epidemiology; Female; Humans; Hypersensitivity; blood; epidemiology; immunology; Immunoglobulin E; blood; Infant; Laboratories; Male; Middle Aged; Odds Ratio; Respiratory Tract Diseases; blood; epidemiology; immunology; Retrospective Studies; Young Adult
From: Biomedical and Environmental Sciences 2014;27(7):495-505
CountryChina
Language:English
Abstract:
OBJECTIVETo investigate the serum total IgE (tIgE) and specific IgE (sIgE) to common allergens among allergic patients in Guangzhou, China.
METHODS7 085 patients were examined for tIgE and sIgE to 15 allergens, based on the protocols of reversed enzyme allergosorbent test and the sandwich enzyme-linked immunosorbent assay.
RESULTS3 758 (53.04%) patients tested positive for tIgE, and 4 640 (65.49%) for sIgE. Der pteronyssinus, Der farinae, eggs, and cow's milk were the most common allergens leading to higher positive rates of sIgE responses. Several peaks of sensitization were: Der pteronyssinus, Der farinae, and Blomia tropicalis at age 10-12; cow's milk at age below 3; eggs at age 4-6. The mean level and positive rate of tIgE tended to increase in subjects sensitized to more allergens. Sensitization to Der pteronyssinus (OR, 1.6; P<0.05), Der farinae (OR, 1.5; P<0.05), Blomia tropicalis (OR, 1.4; P<0.05), Blattella germanica (OR, 1.5; P<0.05), cow's milk (OR, 1.3; P<0.05), and soy beans (OR, 2.0; P<0.05) were independently correlated with allergy-related conditions in preliminary diagnosis.
CONCLUSIONThe major allergens in Guangzhou include Der pteronyssinus, Der farinae, cow's milk, and eggs. Sensitization to these allergens appears to be predictors of allergy-related disorder.