Influence of soy isoflavone on lindane cumulant in sprague-dawley rats.

Author: Yang YANG ¹ ; Yun Bo ZHANG ¹ ; Wei SHENG ¹ ; Zheng Hai FU ¹ ; Zhe WANG ¹ ; Xiao WANG ¹ ; Si Yuan GUAN ² ; Xiao Lin NA ¹
Author Information

1. Department of Environmental Hygiene, Public Health College, Harbin Medical University, Harbin 150086, Heilongjiang, China.
2. Department of Chemistry, Zhejiang University, Hangzhou 310058, Zhejiang, China.
Publication Type:Letter
MeSH: Animals; Brain; metabolism; Estradiol; blood; Female; Isoflavones; pharmacology; Lindane; pharmacology; Rats; Rats, Sprague-Dawley; Soybeans; chemistry; Testosterone; blood; Uterus; drug effects
From: Biomedical and Environmental Sciences 2014;27(8):637-640
CountryChina
Language:English
Abstract: Female Sprague-Dawley rats weighing 60-80 g were given different dosages of soy isoflavones and/or lindane for four weeks. Soy isoflavones was added in feed and lindane was given by oral gavage. We found that soy isoflavones could reduce the level of lindane in rat's serum and brain, but might cause the uterus hyperplasia. Lindane could inhibit the effect of soy isoflavones on uterus and significantly decrease the level of estradiol and testosterone in serum. This study indicated that soy isoflavones could reduce the level of lindane in rat's body. Lindane could reduce the level of hormones and decreased the effect of soy isoflavones on rat's uterus.