Environmental and psycho-social factors related to prostate cancer risk in the Chinese population: a case-control study.

Mei Ling LI; Ji Lin; Jian Guo Hou; Lei XU; Xin Gang Cui; Xing Xing XU; Yong Wei YU; Xue Han; Guo Min Wang; Jian Ming Guo; Dan Feng XU; Timothy C Thompson; Guang Wen Cao; Hong Wei Zhang

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Environmental and psycho-social factors related to prostate cancer risk in the Chinese population: a case-control study.

Author: Mei Ling LI ¹ ; Ji LIN ¹ ; Jian Guo HOU ² ; Lei XU ³ ; Xin Gang CUI ⁴ ; Xing Xing XU ⁵ ; Yong Wei YU ⁶ ; Xue HAN ⁷ ; Guo Min WANG ³ ; Jian Ming GUO ³ ; Dan Feng XU ⁴ ; Timothy C THOMPSON ⁸ ; Guang Wen CAO ¹ ; Hong Wei ZHANG ¹
Author Information

1. Department of Epidemiology, Secondary Military Medical University, Shanghai 200433, China.
2. Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
3. Department of Urology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
4. Department of Urology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
5. Department of Epidemiology, Secondary Military Medical University, Shanghai 200433, China
6. Department of pathology, Changhai Hospital, Second Military Medical University, Shanghai 200032, China.
7. Center for Disease Control and Prevention of Yangpu District, Shanghai 200090, China.
8. Department of Genitourinary Medical Oncology-Research, University of Texas MD Anderson Cancer Center Houston, 77030, USA.
Publication Type:Journal Article
Keywords: Case-control study; Dietary factors; Lifestyle; Prostate cancer; Psycho-social factors
MeSH: Aged; Aged, 80 and over; Animals; Case-Control Studies; China; epidemiology; Food; statistics & numerical data; Humans; Life Style; Male; Middle Aged; Prostatic Neoplasms; epidemiology; etiology; psychology; Stress, Psychological; complications
From: Biomedical and Environmental Sciences 2014;27(9):707-717
CountryChina
Language:English
Abstract:
OBJECTIVETo study the risk environmental and psycho-social factors associated to prostate cancer (PCa) in Chinese population.
METHODS250 PCa patients and 500 controls were enrolled in this case-control study. Information was collected and logistic regression analysis was used to estimate the odds ratios (OR) and 95% confidence intervals (95% CI) for relationship between lifestyle, eating habits and psycho-social factors with PCa risk.
RESULTSGreen vegetables and green tea were associated with a decreased risk of PCa (OR=0.39, 95% CI: 0.28-0.53; OR=0.59, 95% CI: 0.40-0.87, respectively). Family history of PCa (OR=7.16, 95% CI: 2.01-25.49), history of prostate diseases (OR=2.28, 95% CI: 1.53-3.41), alcohol consumption (OR=1.97, 95% CI: 1.33-2.90), red meat consumption (OR=1.74, 95% CI: 1.20-2.52), barbecued (OR=2.29, 95% CI: 1.11-4.73) or fried (OR=2.35, 95% CI: 1.24-4.43) foods were related with increased PCa risk. Negative psycho-social factors including occupational setbacks (OR=1.61, 95% CI: 1.00-2.59), marital separation (OR=1.94, 95% CI: 1.29-2.91), self-contained suffering (OR=2.37, 95% CI: 1.58-3.55), and high sensitivity to the personal comments (OR=1.73, 95% CI: 1.18-2.54) were related to PCa.
CONCLUSIONRegular consumption of green vegetables and green tea may suggest protective effects on PCa. Alcohol consumption, red meat consumption and barbecued or fried foods were associated with PCa. Negative psycho-social factors may also play a role in the incidence of PCa in Chinese population.