X-ray-induced expression changes of TNFSF4 gene in human peripheral blood.

Author: Shi En LI ¹ ; Fei GUO ¹ ; Ping WANG ² ; Lin HAN ² ; Yan GUO ¹ ; Xi Ai WANG ² ; Jie LI ² ; Yu Min LYU ³ ;
Author Information

1. College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
2. Henan Institute of Occupational Medicine, Zhengzhou 450052, Henan, China.
3. College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China
Publication Type:Letter
MeSH: Adult; Aged; Biomarkers; blood; Blood Cells; radiation effects; Dose-Response Relationship, Radiation; Female; Healthy Volunteers; Humans; Male; Middle Aged; OX40 Ligand; blood; X-Rays; Young Adult
From: Biomedical and Environmental Sciences 2014;27(9):729-732
CountryChina
Language:English
Abstract: This study examined ionizing radiation-induced tumor necrosis factor (ligand) superfamily, member 4 (TNFSF4) mRNA expression changes in human peripheral blood cells and their distribution in a normal population. The results showed that expression level of TNFSF4 mRNA exhibited a dose-dependent response after different irradiation doses, but that was independent of incubation time post-irradiation. Moreover, it was not affected by age and gender in 51 healthy donors. Our studies indicate that TNFSF4 can be considered as a candidate gene to develop a new biodosimeter.