A Fatal Spontaneous Gas Gangrene due to Clostridium perfringens during Neutropenia of Allogeneic Stem Cell Transplantation: Case Report and Literature Review.
- Author:
Hae Lim LEE
1
;
Sung Yeon CHO
;
Dong Gun LEE
;
Yumi KO
;
Ji In HYUN
;
Bo Kyoung KIM
;
Jae Hyun SEO
;
Jung Woo LEE
;
Seok LEE
Author Information
- Publication Type:Case Report
- Keywords: Gas Gangrene; Clostridium perfringens; Neutropenia; Stem Cell Transplantation
- MeSH: Adult; Anti-Bacterial Agents; Buttocks; Clostridium; Clostridium perfringens*; Debridement; Gas Gangrene*; Humans; Immunosuppression; Intestines; Mortality; Neutropenia*; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Skin; Stem Cell Transplantation*; Thigh
- From:Infection and Chemotherapy 2014;46(3):199-203
- CountryRepublic of Korea
- Language:English
- Abstract: Most cases of gas gangrene caused by Clostridium species begin with trauma-related injuries but in rare cases, spontaneous gas gangrene (SGG) can occur when patients have conditions such as advanced malignancy, diabetes, or immunosuppression. Clostridium perfringens, a rare cause of SGG, exists as normal flora of skin and intestines of human. Adequate antibiotics with surgical debridement of infected tissue is the only curative therapeutic management. Mortality rate among adults is reported range of 67-100% and majority of deaths are occurred within 24 hours of onset. We experienced a case of SGG on the trunk, buttock and thigh in a neutropenic patient with acute lymphoblastic leukemia. His clinical course was rapid and fatal during pre-engraftment neutropenic period of allogeneic stem cell transplantation.
