Serum levels of IL-13 and TNF-alpha in children with Mycoplasma pneumoniae pneumonia.
- Author:
Yin-Fang LI
1
;
Yin YU
;
Zhi-Fang LU
Author Information
- Publication Type:Journal Article
- MeSH: Child; Child, Preschool; Female; Humans; Infant; Interleukin-13; blood; Male; Pneumonia, Bacterial; immunology; Pneumonia, Mycoplasma; immunology; Respiratory Sounds; immunology; Tumor Necrosis Factor-alpha; blood
- From: Chinese Journal of Contemporary Pediatrics 2010;12(4):275-277
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo examine serum levels of interleukin-13 (IL-13) and tumor necrosis factor alpha (TNF-alpha) in children with Mycoplasma pneumoniae (MP) pneumonia.
METHODSEighty children with MP pneumonia complicated by wheezing or without (n=40 each), 40 children with pneumonia from non-MP infection and 40 healthy children were enrolled. Serum levels of IL-13 and TNF-alpha were measured using ELISA.
RESULTSThe serum levels of IL-13 and TNF-alpha in the MP pneumonia group were significantly higher than those in non-MP pneumonia group and the healthy control group (P<0.01). The children with MP pneumonia complicated by wheezing had increased serum levels of IL-13 (214.6 + or - 67.2 ng/L vs 189.6 + or - 52.1 ng/L; P<0.01) and TNF-alpha(0.55 + or - 0.13 ng/mL vs 0.42 + or - 0.16 ng/mL; P<0.01)compared with those without wheezing.
CONCLUSIONSThe increase in serum levels of IL-13 and TNF-alpha may play important roles in the pathogenesis of MP pneumonia and wheezing attack in children.
