Cerebral perfusion SPECT imaging for assessment of the effect of hyperbaric oxygen therapy on patients with postbrain injury neural status.
- Author:
Xiao-yan SHI
1
;
Zhong-quan TANG
;
Bing XIONG
;
Jian-xiu BAO
;
Da SUN
;
Yun-qiu ZHANG
;
Yu YAO
Author Information
- Publication Type:Clinical Trial
- MeSH: Adolescent; Adult; Aged; Brain; diagnostic imaging; physiopathology; Brain Injuries; diagnostic imaging; therapy; Cerebrovascular Circulation; physiology; Chi-Square Distribution; Child; Cysteine; analogs & derivatives; Female; Follow-Up Studies; Humans; Hyperbaric Oxygenation; methods; Injury Severity Score; Male; Middle Aged; Organotechnetium Compounds; Probability; Reference Values; Risk Assessment; Sensitivity and Specificity; Tomography, Emission-Computed, Single-Photon; Treatment Outcome
- From: Chinese Journal of Traumatology 2003;6(6):346-349
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo evaluate the effects of hyperbaric oxygen (HBO) therapy on patients with postbrain injury neural status.
METHODSTwo to 4 courses of HBO therapy and/or medications were used to treat 320 patients who were randomly divided into two groups. Assessment was made with (99m)Tc-ethyl cysteinate dimer ( (99m)Tc-ECD) single photon emission computed tomography (SPECT) before and after treatment.
RESULTSThere was a significant difference between the HBO therapy group and the non-HBO therapy group. HBO therapy was superior to medication treatment alone in the recovery of clinical symptoms, control of epilepsy, and resolution of hydrocephalus (P<0.01).
CONCLUSIONSHBO therapy has specific curative effects on patients with postbrain injury neural status, and (99m)Tc-ECD SPECT could play an important role in diagnosing postbrain injury neural status and monitoring the therapeutic effects of HBO.
