Biocompatibility of polyurethane-BaFe(12)O(19 ) composite microsphere as a new endovascular embolization material.
- Author:
Zai-Yu GUO
1
;
Lian-Ting MA
;
Jun LI
;
Hai-Lin QIN
;
Hao DU
;
Hong-Lian DAI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Barium Compounds; chemistry; toxicity; Biocompatible Materials; Cell Line, Tumor; Embolization, Therapeutic; instrumentation; Ferric Compounds; chemistry; toxicity; Microspheres; Polyurethanes; chemistry; toxicity; Toxicity Tests
- From: Journal of Southern Medical University 2008;28(6):1002-1004
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the biocompatibility of polyurethane-BaFe(12)O(19) magnetic composite microsphere as a new endovascular embolization material.
METHODSThe biocompatibility of BaFe(12)O(19) particle was evaluated in vitro using Ames test, cell toxicity test, acute and subacute systemic toxicity test, hemolysis test, bleeding time and clotting time test and blood clotting function assay.
RESULTSAmes test showed that the MR values of this particle leaching solution were all less than 2 without mutagenicity. Cell toxicity test showed that leaching solution at different concentrations had grade I toxicity on L929 cells. Acute and subacute systemic toxicity test showed that the experimental animals had good general condition without obvious pathological abnormality. The hemolysis rate of experimental group was 2.43%, which met the ISO standard (no more than 5%). The bleeding time and clotting time in mice were comparable between the experimental group and control group (P>0.05). There were no significant differences in blood clotting function between experimental group and control group (P>0.05).
CONCLUSIONThe material has no obvious toxicity or mutagenicity, and does not cause hemolysis or hemopexis or affect the bleeding time and clotting time. Polyurethane-BaFe(12)O( 19) particle possesses satisfactory biocompatibility.
