Expression of TM4SF9 in human trophoblasts.
- Author:
Tian-Yang GAO
1
;
Yan-Hong YU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Choriocarcinoma; metabolism; Chorionic Villi; metabolism; Female; Humans; Hydatidiform Mole; metabolism; Hydatidiform Mole, Invasive; metabolism; Immunohistochemistry; Membrane Proteins; biosynthesis; Pregnancy; Tetraspanins; Trophoblastic Neoplasms; metabolism; Trophoblasts; metabolism; Uterine Neoplasms; metabolism
- From: Journal of Southern Medical University 2008;28(6):1080-1082
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of TM4SF9 in the villi of early pregnancy, hydatidiform mole, invasive hydatidiform mole and chorionic carcinoma tissue.
METHODSImmunohistochemistry was used to detect the expression of TM4SF9 in normal villi of early pregnancy, hydatidiform mole, invasive hydatidiform mole and chorionic carcinoma tissues.
RESULTSTM4SF9 was expressed in the cytotroblasts but not in the syncytiotrophoblast of normal villi. The intensity of TM4SF9 expression increased in the order of normal villi, hydatidiform mole, invasive hydatidiform mole and chorionic carcinoma, with strong positivity rates of 0, 10%, 36.4% and 100%, respectively, showing significant differences between the samples (P<0.001).
CONCLUSIONTM4SF9 expression in the trophoblasts may relate to their invasiveness and play an important role in the metastasis of trophoblastic tumor.
