Mechanism of the effect of Tongluo Recipe against glomerular sclerosis in rats.
- Author:
Xi-li WU
1
;
Wan-sen SUN
;
Wang-gang ZHANG
;
Zhu WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Collagen Type IV; biosynthesis; Drugs, Chinese Herbal; therapeutic use; Fibronectins; biosynthesis; Glomerulosclerosis, Focal Segmental; drug therapy; metabolism; pathology; Kidney; drug effects; metabolism; pathology; Male; Phytotherapy; Random Allocation; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta1; biosynthesis; Treatment Outcome
- From: Journal of Southern Medical University 2008;28(7):1198-1201
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of Tongluo Recipe on the expression of collagen IV (Col IV), fibronectin (FN), laminin (LN), transforming growth factor-beta1 (TGF-beta1) in rat renal tissues and explore the mechanism underlying these effects in rats with glomerular sclerosis.
METHODSThe pathological changes in the renal tissues of rats with glomerular sclerosis were observed microscopically, and the expressions of Col IV, FN, LN, and TGF-beta1 were detected using immunohistochemical staining and image analysis system.
RESULTSTongluo Recipe significantly decreased the expressions of Col IV, FN, LN and TGF-beta1 in the renal tissue of rats with glomerular sclerosis (P<0.05 or P<0.01) and obviously alleviated the renal pathologies (P<0.01).
CONCLUSIONThe therapeutic effects of Tongluo Recipe are probably mediated by lowered expressions of Col IV, FN, LN and TGF-beta1.
