Role of bile in rat gastric mucosal injury due to duodenogastric reflux.
- Author:
Yin-xue SONG
1
;
Jun GONG
;
Jian-tao WU
;
Juan GENG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Bile; physiology; Duodenogastric Reflux; physiopathology; Gap Junctions; pathology; Gastric Mucosa; pathology; Male; Random Allocation; Rats; Rats, Sprague-Dawley
- From: Journal of Southern Medical University 2008;28(7):1219-1222
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the effect of bile in inducing gastric mucosal injury in rats.
METHODSSD rats were divided into 4 groups, namely bile duct ligation group, duodenogastric reflux (DGR) group, DGR plus bile duct ligation group and normal control group. The pathological changes in the gastric mucosa and tight junction 3 months after gastrojejunostomy were observed and compared with the findings in the normal control rats.
RESULTSCompared with the rats in DGR plus bile duct ligation group, the rats in DGR group showed obvious gastric mucosal hyperemia, foveolar hyperplasia and severely impaired tight junction between the gastric mucosal cells.
CONCLUSIONBile plays an important role in gastric mucosal injury due to DGR.
