Preoperative intra-arterial chemotherapy for progressive lower rectal cancer.
- Author:
Yun-qiang TANG
1
;
Zhi-ming TAN
;
Jia-kang WANG
;
Ri-jie TANG
;
Jun WANG
;
Hong-yu ZHAO
;
Cong MAI
;
Xiang-liang ZHANG
;
Shu-zhong CUI
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma; drug therapy; mortality; surgery; Antineoplastic Combined Chemotherapy Protocols; administration & dosage; therapeutic use; Chemotherapy, Adjuvant; Female; Humans; Infusions, Intra-Arterial; Male; Middle Aged; Preoperative Care; Rectal Neoplasms; drug therapy; mortality; surgery; Survival Rate
- From: Journal of Southern Medical University 2008;28(7):1247-1248
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the therapeutic effect of preoperative regional intra-arterial chemotherapy (PRAC) on progressive lower rectal cancer.
METHODSForty-five patients with progressive lower rectal cancer were divided into groups A (23 cases) and B (22 cases) for treatment with PRAC 1 to 2 weeks prior to surgical tumor resection or with surgical resection only, respectively.
RESULTSPRAC caused obvious tissue degeneration and necrosis of rectal cancer with a total effective rate of 95.65%. The rates of radical resection in groups A and B were 91.3% and 72.27%, respectively. The 1-year postoperative survival rates of the two groups were 95.65% and 86.36%, with 3-year survival of 89.96% and 68.18%, and 3-year postoperative recurrence rates of 8.69% and 27.27%, respectively. The anal preservation rates of the two groups were 78.26% and 59.09%.
CONCLUSIONPRAC can increase radical resection rates, promote the postoperative survival and anal preservation rate, and lower the recurrence rate in patients with lower rectal cancer.
