Allogeneic leukocyte immunization combined with IVF-ET for treatment of infertility induced by recurrent spontaneous abortion.
- Author:
Ling-hong KONG
1
;
Zhong LIU
;
Hong LI
;
Si-mei CHEN
;
Fu-qi XING
Author Information
- Publication Type:Journal Article
- MeSH: Abortion, Habitual; physiopathology; Adoptive Transfer; methods; Adult; Embryo Transfer; Female; Fertilization in Vitro; methods; Humans; Infertility, Female; physiopathology; therapy; Pregnancy; Pregnancy Outcome; Treatment Outcome
- From: Journal of Southern Medical University 2008;28(7):1300-1301
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of allogeneic leukocyte immunization combined with in vitro fertilization-embryo transfer (IVF-ET) for treatment of infertility induced by habitual abortion.
METHODSAllogeneic leukocyte immunization was performed in 9 patients with infertility induced by habitual abortion, with another 9 patients undergoing IVF-ET without habitual abortion as the control group. All the patients were treated with long GnRH-a protocols. The infertility patients with recurrent spontaneous abortion history were immunized with lymphocytes from the husband for before IVF-ET and after clinical pregnancy.
RESULTSThe fertilization rates of the immunotherapy group and control group were 81.3% and 82.2%, respectively, showing no significant difference (P>0.05). Five patients in each group had clinical pregnancy, and a twin pregnancy occurred in the control group. The embryo implantation rates were also comparable between the two groups (22.7% vs 28.6%, P>0.05). All the fetuses resulted from IVF-ET developed normally and were healthily delivered.
CONCLUSIONAllogeneic leukocyte immunotherapy along with IVF-ET is effective for treatment of infertility resulting from recurrent spontaneous abortion.
