Effects of Nickel Compounds on Sister Chromatid Exchanges and Chromosome Aberrations in Human Cultured Lymphocytes.
- Author:
In Dam HWANG
1
;
No Suk KI
;
Jeong Sang LEE
;
Sang Kyu LEE
Author Information
1. Department of Preventive Medicine and Public Health, College of Medicine, Chonbuk National Universily, Korea.
- Publication Type:Original Article
- MeSH:
Chromosome Aberrations*;
Chromosome Breakage;
Cytogenetics;
Humans;
Humans*;
Lymphocytes*;
Nickel*;
Siblings*;
Sister Chromatid Exchange*
- From:Korean Journal of Occupational and Environmental Medicine
1989;1(1):46-51
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Nickel is a carcinogen in nickel refinery workers. Few chromosome studies have been performed on nickel toxicity. Therefore, this study was performed to investigate cytogenetic toxicity of nickel in human cultured lymphocytes by chromosome aberration, and sister chromatid exchange (SCE) which is a sensitive indicator of carcinogen and mutagen. The results indicate that nickel chloride and nickel sulfate led to a increase in SCE frequencies very significantly, although absolute value of SCE was low. In chromosome aberration, chromosome gap was increased to increment of concentration while chromosome break was not.
