The advance of model of action in low-dose chronic benzene exposure induced hematotoxicity.
- Author:
Chen GAO
1
;
Zhengbao ZHANG
1
;
Liping CHEN
1
;
Wen CHEN
2
;
Email: CHENWEN@MAIL.SYSU.EDU.CN.
Author Information
1. School of Pubilc Health, Sun Yat-sen University, Guang zhou 510080, China.
2. School of Pubilc Health, Sun Yat-sen University, Guang zhou 510080, China
- Publication Type:Journal Article
- MeSH:
Benzene;
toxicity;
Carcinogens;
toxicity;
Epigenesis, Genetic;
Humans;
Occupational Exposure
- From:
Chinese Journal of Preventive Medicine
2015;49(9):840-843
- CountryChina
- Language:Chinese
-
Abstract:
Benzene is classified as Group 1 carcinogen by IARC. It has been found that benzene induces hematotoxicity even in low dose exposure. The identification of key events during benzene induced hematotoxicty leads to adjustment of occupational exposure limits of benzene. In this review, we focus on the exposure, metabolism, target organs, key epigenetic changes, toxicty effects and end points of low-dose chronic benzene exposure induced hematotoxicity and finally discuss the perspectives on the future study of this area.
