Association of Depression with Inflammation and Cardiovascular Risk Factors in End Stage Renal Disease Patients on Hemodialysis.
- Author:
Young Youl HYUN
1
;
Sun Chul KIM
;
Se Won OH
;
Jin Joo CHA
;
Hye Won KIM
;
Jae Won LEE
;
Yoon Seok CHOI
;
Hye Min CHOI
;
Chang Su BOO
;
Gang Jee KO
;
Sang Kyung JO
;
Won Yong CHO
;
Hyoung Kyu KIM
Author Information
1. Department of Internal Medicine, Korea University College of Medicine, Korea. sang-kyung@korea.ac.kr
- Publication Type:Original Article
- Keywords:
Depression;
Hemodialysis;
Inflammation;
Cardiovascular disease
- MeSH:
Cardiovascular Diseases;
Cause of Death;
Depression;
Ferritins;
Genotype;
Humans;
Hypertrophy, Left Ventricular;
Inflammation;
Interleukin-10;
Kidney Failure, Chronic;
Medical Records;
Prevalence;
Renal Dialysis;
Risk Factors;
Tumor Necrosis Factor-alpha
- From:Korean Journal of Nephrology
2008;27(4):452-457
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Depression is associated with increased inflammation and cardiovascular disease. And in patients with end stage renal disease (ESRD), depression is a common problem and cardiovascular disease is the main cause of death. The aim of this study is to investigate the association of depression with various inflammatory markers and with some cardiovascular risk factors in ESRD patients on hemodialysis METHODS: 53 patients with ESRD on maintenance hemodialysis were divided into depressive symptom (BDI> or =11) group and control (BDI < 11) group by the 21-items Becks depression inventory (BDI). We collected patients characteristics and laboratory measurements by medical records. And then, we measured the levels of IL-10 and TNF-alpha a and analyzed the genotype of IL-10 and TNF-alpha a promoter area. RESULTS: The levels of TNF-alpha, CRP and ferritin were significantly higher in depressive symptom group (p=0.001, 0.04, 0.02) and IL-10 concentration tended to be lower in depressive symptom group (p= 0.05). The prevalence of left ventricular hypertrophy was higher in depressive symptom group than in the control group (44% vs 9%, p=0.01). GG genotype known as high IL-10 producer was less common in depressive symptom group than in control group (8% vs 36%, p=0.039). CONCLUSION: Increased inflammation, high left ventricular hypertrophy prevalence and low ejection fraction were observed in depressive hemodialysis patients. Further prospective study is needed to clarify the role of depression in the development of inflammation and cardiovascular disease in ESRD patients.
