Manganese neurotoxic effect and its susceptibility biomarkers of choice.
- Author:
Hua SHAO
1
,
2
;
Email: CHINASHAOHUA5888@163.COM.
Author Information
1. Shandong Academy of Occupational Health and Occupational Medicines, Jinan 250062, China
2. Email: chinashaohua5888@163.com.
- Publication Type:Journal Article
- MeSH:
Biomarkers;
Disease Susceptibility;
Humans;
Manganese;
Manganese Poisoning;
Neurotoxicity Syndromes;
Occupational Exposure
- From:
Chinese Journal of Preventive Medicine
2015;49(10):856-859
- CountryChina
- Language:Chinese
-
Abstract:
Long-term occupational exposure to manganese might cause manganese poisoning, which would had adverse effects on nervous system of workers. The basal nucleus was damaged and dopaminergic neuron was injuried by manganese. The mechanism could be related with interfering the energy metabolism of central nerve, changing neurotransmitters, activating oxidation system and so on. Genetic factors may also plays a significant role in the neurotoxicity caused by manganese. Study the effects of manganese exposure biomarker, the neurotoxicity of biomarkers and the genetic susceptibility to early and susceptibility biomarkers will contribute to the prevention and control of manganese neurotoxicity.
