A Case of Sub-acute Bacterial Endocarditis associated with a Positive ANCA Serology.
- Author:
Jun Ho CHOI
1
;
Duk Eun JUNG
;
Han Seung RYU
;
Hyeon Jeong KIM
;
Yu Min LEE
;
Jae Hun LEE
;
Ji Eun LEE
;
Jin Ho SHIN
;
Ju Hung SONG
;
Seon Ho AHN
Author Information
1. Department of Internal Medicine, Wonkwang University School of Medicine, Iksan, Korea. ashneph@wonkwang.ac.kr
- Publication Type:Case Report
- Keywords:
Sub-acute bacterial endocarditis;
ANCA;
Vasculitis
- MeSH:
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis;
Antibodies;
Antibodies, Antineutrophil Cytoplasmic;
Cytoplasm;
Diagnostic Errors;
Endocarditis, Bacterial;
Fluorescent Antibody Technique, Indirect;
Glycosaminoglycans;
Humans;
Peroxidase;
Vasculitis
- From:Korean Journal of Nephrology
2008;27(4):476-480
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Antineutrophil cytoplasmic antibodies (ANCA) directed against either proteinase-3 or myeloperoxidase are associated with a limited group of small vessel vasculitic syndromes. C-ANCA is regarded as highly specific for idiopathic ANCA-associated vasculitis (AAV). However, C-ANCA is not specific for Wegeners granulomatosis and has been reported in the course of a variety of infectious conditions. Sub-acute bacterial endocarditis is a notable concern because it may be associated with C-ANCA. The misdiagnosis of bacterial endocarditis as AAV and the administration of immunosuppressive treatment could aggravate the infection. We describe a patient with sub-acute bacterial endocarditis who presented with features mimicking vasculitis and positive C-ANCA by indirect immunofluorescence and for anti-PR3 antibodies by antigen-specific ELISA.
