Effect of early intestinal dripping of jianpi tongli Chinese herbs on serum level IL-2, sIL-2R and IL-12 in patients with gastric cancer after operation.
- Author:
Qing-Sheng YU
1
;
Yi LIU
;
Yong HOU
;
Fuzhong ZHANG
;
Weizhen YI
;
Xiaoming WANG
;
Jianfeng SHUAI
Author Information
- Publication Type:Clinical Trial
- MeSH: Adenocarcinoma; blood; drug therapy; surgery; Adult; Aged; Combined Modality Therapy; Drugs, Chinese Herbal; administration & dosage; Female; Humans; Interleukin-12; blood; Interleukin-2; blood; Intestine, Small; Intubation, Gastrointestinal; Male; Middle Aged; Phytotherapy; Postoperative Period; Receptors, Interleukin-2; blood; Stomach Neoplasms; blood; drug therapy; surgery
- From: Chinese Journal of Integrated Traditional and Western Medicine 2005;25(8):710-713
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the regulation and clinical significance of intestinal dripping of Jianpi Tongli (JPTL) Chinese herbs on levels of serum cytokines, such as interleukin-2 (IL-2), soluble interleukin-2 receptor (sIL-2R) and interleukin-12 (IL-12) in treating patients with gastric cancer (GC) at early post-operational stage.
METHODSSixty patients with GC were randomly divided into two groups, i. e. the studied group (n = 30), treated with JPTL Chinese herbs, and the control group (n = 30) treated with normal saline. The medication was started from the 1st day after operation by intestinal dripping daily, 7 days as one course. Levels of IL-2, sIL-2R and IL-12 were observed before and after operation.
RESULTSSignificant difference was seen on the 7th day post-operation between the studied and the control group, mainly in aspects of obvious increase of IL-2 and decrease of sIL-2R (P <0.05), no significant difference in IL-12 was found (P >0.05) though there was certain improvement. Compared with pre-operation of the same group, significant difference was found in the studied group in the increased IL-2 and IL-12 and decreased sIL-2R on the 7th day post-operation, while no significant difference in these indexes was found in the control group (P >0.05), though certain improvement was shown.
CONCLUSIONEarly intestinal dripping of JPTL Chinese herbs to post-operational patients with GC could improve their immune function, which was of important significance in early preventing the severe complications, improving the prognosis, and elevating the survival rate.
