Comparative study on effect of Tripterygium polyglycosides on mucous immune function of rat models of arthritis induced by collagen II and by adjuvant.
- Author:
Jing ZHOU
1
;
Ning ZHAO
;
Hong-Wei JIA
;
Cheng XIAO
;
Yinghui HE
;
Aiping LU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Arthritis, Experimental; chemically induced; drug therapy; immunology; Collagen Type II; Freund's Adjuvant; Glycosides; pharmacology; Male; Mucous Membrane; immunology; Rats; Rats, Sprague-Dawley; Tripterygium; chemistry
- From: Chinese Journal of Integrated Traditional and Western Medicine 2005;25(8):723-726
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effects of Tripterygium polyglycosides (TWP) on mucous immune function in rat models of arthritis induced respectively with collagen-II induced arthritis (CIA) & adjuvant arthritis (AA).
METHODSCIA and AA model rats were induced by immunization with collagen II emulsified with complete Freund's adjuvant and complete Freund's adjuvant respectively and treated with TWP. Rats' mucus, systemic immunological indexes (peripheral subsets of T cells), local inflammatory factors (IL-6, TNF-alpha, COX-2,and NF-kappaB, etc. ) were observed.
RESULTSIn CIA model group, CD4+ in Peyer's Patch (PP), peripheral CD4+ and CD8+ positive T cells all raised, while in the AA model group, CD4+ lowered and CD8+ raised on PP, with both subsets increased. Effects of TWP on T lymphocyte subsets in PP and blood of the two models were different. High leveled IL-6, TNF-alpha, COX-2 and NF-kappaB expression could be seen in both model groups, and these inflammatory media could be inhibited by TWP.
CONCLUSIONThere exist similarities and differences between the two models in aspects of mucus immune response and effect of TWP on them.
