A Case of Membranoproliferative Glomerulonephritis Associated with Sjogren's Syndrome.
- Author:
Ssang Yong OH
1
;
Hee Jeong CHA
;
Min Su KIM
;
Hyun CHO
;
Hyun Chul CHUNG
;
Jong Soo LEE
;
Jongha PARK
Author Information
1. Department of Internal Medicine, Ulsan University Hospital University of Ulsan College of Medicine, Ulsan, Korea. nepholic@yahoo.co.kr
- Publication Type:Case Report
- Keywords:
Membranoproliferative glomerulonephritis;
Proteinuria;
Sjogrens syndrome;
Vasculitis
- MeSH:
Acidosis;
Adult;
Autoimmune Diseases;
Biopsy;
Connective Tissue Diseases;
Exocrine Glands;
Female;
Glomerulonephritis;
Glomerulonephritis, Membranoproliferative;
Glomerulonephritis, Membranous;
Humans;
Lupus Erythematosus, Systemic;
Nephritis, Interstitial;
Proteinuria;
Sjogren's Syndrome;
Vasculitis;
Xerophthalmia;
Xerostomia
- From:Korean Journal of Nephrology
2008;27(4):508-512
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Sjogrens syndrome is a slowly progressive autoimmune disease characterized by lymphocytic infiltration of the exocrine glands, resulting in the xerostomia and xerophthalmia. In this syndrome, renal involvement includes interstitial nephritis, clinically manifested by hyposthenuria and renal tubular dysfunction with or without acidosis. Glomerulonephritis, however, is a rare finding and there have been few reports of membranous glomerulopathy or membranoproliferative glomerulonephritis (MPGN). We report a 31-year-old female diagnosed as MPGN associated with primary Sjogren's syndrome. She suffered from recurrent epigastric pain, and revealed a moderate proteinuria. Renal biopsy findings were consistent with type I MPGN and thereafter Sjogren's syndrome was diagnosed by further evaluation. She did not meet the criteria to systemic lupus erythematosus or other connective tissue disease. To our knowledge, this is the first report of MPGN associated with Sjogrens syndrome in Korea.
