Effect of oxymatrine on serum matrix metalloproteinase-2 and its inhibitor in patients with chronic hepatitis B and liver cirrhosis.
- Author:
Jiang LIU
1
;
Bai-nian SHI
;
Jian-fang HE
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Alkaloids; therapeutic use; Collagen Type IV; blood; Female; Hepatitis B, Chronic; complications; drug therapy; enzymology; Humans; Hyaluronic Acid; blood; Laminin; blood; Liver Cirrhosis; complications; drug therapy; enzymology; Male; Matrix Metalloproteinase 2; blood; Middle Aged; Quinolizines; therapeutic use; Sophora; Tissue Inhibitor of Metalloproteinase-2; blood
- From: Chinese Journal of Integrated Traditional and Western Medicine 2005;25(11):989-992
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of oxymatrine on the level of serum matrix metalloproteinase-2 (MMP-2) and its inhibitor (TIMP-2) in patients with chronic hepatitis B (CHB) and post-hepatitis B liver cirrhosis (LC), as well as on liver fibrosis indexes as hyaluronic acid (HA), laminin (LN) and IV type collagen (IV C).
METHODSChanges of all the above-mentioned indexes in patients with CHB (n = 36) and LC (n = 36) before and after treatment were determined, and the relationship of MMP-2 and TIMP-2 with liver fibrosis indexes were analyzed.
RESULTSOxymatrine could decrease the levels of MMP-2, HA, LN and IV C in patients with severe or moderate CHB and LC of Child-pugh A, B and C grade, as compared with the data before treatment (P < 0.05). Serum level of MMP-2 and TIMP-2 was well correlated with the levels of liver cirrhosis indexes.
CONCLUSIONMMP-2 and TIMP-2 can be used as a reference for evaluating the degree of LC, and oxymatrine has a certain anti-LC effect.
