Clinical observation on treatment of early diabetic nephropathy by milkvetch injection combined with captopril.
- Author:
Yi-hong LIU
1
;
Li YANG
;
Ju LIU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Albuminuria; drug therapy; Astragalus membranaceus; Captopril; therapeutic use; Diabetes Mellitus, Type 2; drug therapy; Diabetic Nephropathies; drug therapy; Drug Therapy, Combination; Drugs, Chinese Herbal; administration & dosage; Female; Humans; Injections; Male; Middle Aged; Phytotherapy
- From: Chinese Journal of Integrated Traditional and Western Medicine 2005;25(11):993-995
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the therapeutic effect of milkvetch injection (MI) combined with Captopril on early diabetic nephropathy (EDN).
METHODSA total of 69 EDN patients were randomly divided into three groups, with 23 in each group. Besides the conventional hypoglycemic therapy, patients in Group A Captopril, in Group B MI plus Captopril and in Group C MI were given respectively. The therapeutic course for all was 3 months. The related indices of EDN before and after treatment were measured and compared.
RESULTSAfter treatment, the blood pressure significantly lowered after treatment in Group A and B (P<0.01), but unchanged in Group C; the levels of blood glucose and HbA1c significantly decreased in Group B and C (P < 0.05 or P<0.01), and significant difference was shown in comparison of Group B with Group A (P<0.05); levels of 24hrs urinary albumin excretion (UAER), blood urea nitrogen (BUN) and serum creatinine (SCr) significantly decreased in all 3 groups, and the decrement in Group B was more significant than that in the other two groups (P <0.05).
CONCLUSIONMI combined with Captopril can not only decrease blood pressure, blood glucose and HbA1c, but also significantly decrease the UAER in treating EDN.
