A review of clinical and histological parameters associated with contralateral neck metastases in oral squamous cell carcinoma.
- Author:
Song FAN
1
;
Qiong-Lan TANG
;
Ying-Jin LIN
;
Wei-Liang CHEN
;
Jin-Song LI
;
Zhi-Quan HUANG
;
Zhao-Hui YANG
;
You-Yuan WANG
;
Da-Ming ZHANG
;
Hui-Jing WANG
;
Eduardo DIAS-RIBEIRO
;
Qiang CAI
;
Lei WANG
Author Information
- Publication Type:Journal Article
- MeSH: Carcinoma, Squamous Cell; pathology; radiotherapy; secondary; surgery; Humans; Lymph Nodes; pathology; Lymphatic Metastasis; Mouth Floor; pathology; Mouth Neoplasms; pathology; radiotherapy; surgery; Neck; pathology; Neck Dissection; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasm Staging; Radiotherapy, Adjuvant
- From: International Journal of Oral Science 2011;3(4):180-191
- CountryChina
- Language:English
- Abstract: Oral squamous cell carcinoma (OSCC) has a high incidence of cervical micrometastases and sometimes metastasizes contralaterally because of the rich lymphatic intercommunications relative to submucosal plexus of oral cavity that freely communicate across the midline, and it can facilitate the spread of neoplastic cells to any area of the neck consequently. Clinical and histopathologic factors continue to provide predictive information to contralateral neck metastases (CLNM) in OSCC, which determine prophylactic and adjuvant treatments for an individual patient. This review describes the predictive value of clinical-histopathologic factors, which relate to primary tumor and cervical lymph nodes, and surgical dissection and adjuvant treatments. In addition, the indications for elective contralateral neck dissection and adjuvant radiotherapy (aRT) and strategies for follow-up are offered, which is strongly focused by clinicians to prevent later CLNM and poor prognosis subsequently.
