Investigation of basement membrane proteins in a case of granular cell ameloblastoma.
- Author:
Puangwan LAPTHANASUPKUL
1
;
Sopee POOMSAWAT
;
Jira CHINDASOMBATJAROEN
Author Information
- Publication Type:Case Reports
- MeSH: Adult; Ameloblastoma; chemistry; pathology; Basement Membrane; chemistry; Cell Adhesion Molecules; analysis; Collagen Type IV; analysis; Female; Fibronectins; analysis; Humans; Keratinocytes; chemistry; pathology; Laminin; analysis; Mandibular Neoplasms; chemistry; pathology; Membrane Proteins; analysis
- From: International Journal of Oral Science 2012;4(1):45-49
- CountryChina
- Language:English
- Abstract: Granular cell ameloblastoma is a rare, benign neoplasm of the odontogenic epithelium. A case of massive granular cell ameloblastoma in a 44-year-old Thai female is reported. Histopathological features displayed a follicular type of ameloblastoma with an accumulation of granular cells residing within the tumor follicles. After treatment by partial mandibulectomy, the patient showed a good prognosis without recurrence in a 2-year follow-up. To characterize the granular cells in ameloblastoma, we examined the expression of basement membrane (BM) proteins, including collagen type IV, laminins 1 and 5 and fibronectin using immunohistochemistry. Except for the granular cells, the tumor cells demonstrated a similar expression of BM proteins compared to follicular and plexiform ameloblastomas in our previous study, whereas the granular cells showed strong positivity to laminins 1 and 5 and fibronectin. The increased fibronectin expression in granular cells suggests a possibility of age-related transformation of granular cells in ameloblastoma.
