Establishment of a goat model of tibial bone hole defect suitable for repair using injectable bone materials.
- Author:
Wen-jun CHENG
1
;
Dan JIN
;
Guo-xian PEI
;
Gang GUO
;
Xu LI
;
Da-yong XIANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Biocompatible Materials; administration & dosage; Bone Regeneration; Bone Substitutes; administration & dosage; Disease Models, Animal; Female; Goats; Injections; Male; Tibia; injuries; Tibial Fractures; therapy; Tissue Engineering
- From: Journal of Southern Medical University 2010;30(1):35-37
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare a goat model of tibial bone hole defect suitable for studies of bone defect repair using tissue-engineered injectable bone materials.
METHODSA circular hole bone defect 1.2 cm in diameter was induced below the tibial medial plateau of the goat. X-ray, histological inspection, and image analysis were carried out to evaluate the validity of the model in simulating limb bone defect for the study of tissue-engineered injectable bone materials.
RESULTSAt 4 and 8 weeks after the operation, neither X-ray nor histological examination showed obvious bone tissues in the bone defect. Image analysis showed a area of new bone tissue formation of (8.79 - or + 3.63)% in the total defect area at 4 weeks, which increased to (15.41 - or + 4.21)% at 8 weeks.
CONCLUSIONThe goat model of tibial bone hole defect established in this study is suitable for studying the ability of injectable bone materials for repairing limb bone defect, and offers a simple and reliable means to simulate the local condition of bone regeneration and mechanical environment of bone defect in the limbs.
