Survey of the evolutionary characteristics of influenza H1N1 hemagglutinin gene HA1 in 2000-2009.
- Author:
Ni-sha WANG
1
;
Wen-li MA
;
Hai-quan ZHAO
;
Min WEI
;
Bao ZHANG
;
Wen-ling ZHANG
;
Xing-yu XIANG
Author Information
- Publication Type:Journal Article
- MeSH: Antigenic Variation; China; epidemiology; Computational Biology; Genes, Viral; Hemagglutinin Glycoproteins, Influenza Virus; genetics; Humans; Influenza A Virus, H1N1 Subtype; genetics; Influenza, Human; epidemiology; virology; Mutation; Phylogeny
- From: Journal of Southern Medical University 2010;30(1):92-95
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the global evolutionary characteristics of hemagglutinin gene HA1 of influenza H1N1 infecting different species during 2000-2009.
METHODSThe target sequences were downloaded from NCBI and analyzed using bioinformatic software to construct the phylogenetic tree.
RESULTSThe HA1 amino acid sequences of influenza H1N1 contained four mutated antigenic sites and receptor-binding sites, and the novel influenza virus shared most of the mutated amino acid sites with swine H1N1 influenza virus.
CONCLUSIONThe HA1 gene of novel influenza virus might originate from the early swine H1N1 influenza virus from North America, and in the evolutionary process, a number of important sites of HA1 gene mutated to result in the outbreak of influenza.
