Effect of the active component isolated from the alcohol extract of Dioscorea cirrhosa Lour on blood pressure of rats.
- Author:
Cheng-lai XIA
1
;
Chao ZHONG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antihypertensive Agents; isolation & purification; pharmacology; Blood Pressure; drug effects; Dioscorea; chemistry; Drugs, Chinese Herbal; pharmacology; Male; Plant Extracts; pharmacology; Rats; Rats, Sprague-Dawley
- From: Journal of Southern Medical University 2010;30(1):160-162
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo isolate the active component from Dioscorea cirrhosa Lour and test its activity in lowering blood pressure.
METHODSThe serial components were obtained from the total extract, ligroin extract, ethyl acetate, n-butyl alcohol extract and water extract. The isolated active components were administered in rats via the common carotid artery canulation and tail vein injection to test their effects on blood pressure.
RESULTSThe component A isolated and purified from normal butanol showed obvious effect in lowering the blood pressure of rats.
CONCLUSIONThe isolated active component from Dioscorea cirrhosa Lour possesses obvious blood pressure-lowering activity.
