Effect of skeletal muscle contraction on bone capillary permeability: an experimental study in rabbits.
- Author:
Yu ZHNAG
1
;
Dan JIN
;
Li-chao WANG
;
Yu QIN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Capillary Permeability; physiology; Female; Implants, Experimental; Muscle Contraction; physiology; Muscle, Skeletal; physiology; Rabbits; Random Allocation; Tibia; blood supply; surgery; Transcutaneous Electric Nerve Stimulation
- From: Journal of Southern Medical University 2010;30(2):295-297
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the effect of muscle contraction on bone capillary permeability.
METHODSThirty female New Zealand white rabbits were randomly divided into the experimental and control groups (n=15). The bone chambers were implanted medially into the right tibiae of the rabbit, and in the experimental group, the rabbits were stimulated by transcutaneous electrical nerve stimulator (TENS) at 4 Hz (1 h/day, 6 days/week) starting from week 2. From week 3, intravital microscopic observation was carried out weekly till week 10, and the vasculature in the tibiae was observed under fluorescent microscope with FITC and RITC staining. All the images were analyzed by Metamorph program.
RESULTSThe bone capillary permeability increased significantly in the experimental group.
CONCLUSIONSkeletal muscle contraction can increase the capillary permeability.
