Chromosome karyotype and Y chromosome microdeletion analysis in 133 idiopathic male infertile patients.
- Author:
Yan JI
1
;
Hong-jia XU
;
Jian-chu HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Chromosome Deletion; Chromosomes, Human, Y; genetics; Humans; Infertility, Male; genetics; Karyotyping; Male; Sex Chromosome Aberrations; Sex Chromosome Disorders of Sex Development; genetics; Young Adult
- From: Journal of Southern Medical University 2010;30(2):388-390
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the relationship between chromosomal abnormalities and Y chromosome microdeletions in idiopathic male infertile patients.
METHODSKaryotypic analysis and PCR were carried out in 133 male idiopathic infertile patients for chromosome karyotype and Y chromosome microdeletion analysis.
RESULTSOf the 133 patients, 25 (18.80%) were found to have chromosome abnormalities, and 12 (9.02%) were found to have Y chromosome microdeletions including 2 with varicocele and 2 with cryptorchism. Four patients had both chromosomal abnormalities and Y chromosome microdeletions.
CONCLUSIONThe chromosomal abnormalities and Y chromosome microdeletions may play an important role in idiopathic male infertility, suggesting the importance of examinations of chromosomal abnormalities and Y chromosome microdeletions in such patients.
