Therapeutic effect of ketogenic diet for refractory epilepsy in children: a prospective observational study.
- Author:
Deng-Na ZHU
1
;
Meng-Meng XIE
;
Jun-Hui WANG
;
Jun WANG
;
De-You MA
;
Li SUN
;
Lin-Chen LI
;
Ming-Mei WANG
Author Information
- Publication Type:Journal Article
- MeSH: Child, Preschool; Diet, Ketogenic; adverse effects; Electroencephalography; Epilepsy; diet therapy; physiopathology; Female; Humans; Infant; Male; Prospective Studies; Recurrence
- From: Chinese Journal of Contemporary Pediatrics 2014;16(5):513-517
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the clinical efficiency, electroencephalogram (EEG) changes and cognitive improvements of ketogenic diet (KD) in children with refractory epilepsy.
METHODSTwenty pediatric patients (7-61 months in age) with refractory epilepsy were recruited between August 2012 and August 2013. KD therapy was performed on all participants for at least 3 months based on a fasting initiation protocol with the lipid-to-nonlipid ratio being gradually increased to 4 : 1. Seizure frequency, type and degree were recorded before and during KD therapy. A 24 hours video-electroencephalogram (V-EEG) examination and Gesell Developmental Scale assessment were performed prior to KD therapy, and 3, 6, 9 months after KD therapy.
RESULTSSix patients became seizure free after KD therapy, with a complete control rate of 30%. Seizure frequency reduction occurred in 13 (65%) patients, EEG improvement in 8 (40%) patients, and improvement in Gesell Developmental Scales (gross motor and adaptability in particular) in 6 (30%) patients. The KD therapy-related side effects were mild.
CONCLUSIONSKD therapy is safety and effective in reducing seizure frequency and improving EEG and cognitive function in children with refractory epilepsy.
